Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FGF1 | P05230 | 8/20 | 0.40 |
| ▸ | VEGFA | P15692 | 6/20 | 0.40 |
| ▸ | FGF2 | P09038 | 3/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.40 |
| ▸ | CD209 | Q9NNX6 | 2/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | MDK | P21741 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18056168 | 1.00 | MMP13 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL16644758 | 0.92 | MMP13 (0.47) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL19860903 | 0.89 | CD209 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL19860868 | 0.89 | CD209 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL16640814 | 0.89 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL16640822 | 0.89 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL18161289 | 0.89 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL18056139 | 0.88 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL16644897 | 0.88 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 | |
| SCHEMBL16644871 | 0.88 | FGF1 (0.42) | MMP13ALDH1A1CYP3A4ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | MMP13 3215/4885ALDH1A1 3285/4885CYP3A4 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.