Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ELANE | P08246 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL8168043 | 0.94 | CYP2C19 (0.58) | CYP2C19ELANEMAPTKDM4EGAA | |
| Acrylic Acid SCHEMBL20918477 | 0.94 | CYP2C19 (0.58) | CYP2C19ELANEMAPTKDM4EGAA | |
| Acrylic Acid SCHEMBL1591920 | 0.94 | CYP2C19 (0.58) | CYP2C19ELANEMAPTKDM4EGAA | |
| Acrylic Acid SCHEMBL27988742 | 0.94 | CYP2C19 (0.58) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL26704 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL21838264 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL22902902 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL1185726 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL9227026 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA | |
| SCHEMBL17917072 | 0.93 | CYP2C19 (0.59) | CYP2C19ELANEMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207144-A1 | OIL-IN-WATER DESPERSIONS OF HYDROPHOBIC AGENTS AND POLYMER OR COPOLYMER FRAGMENTS, OR COMBINATIONS THEREOF, AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | US | claimed |
| CN-116997315-A | Cosmetic composition for improving skin and use method thereof | 莱雅公司 | 2023-11-03 | — | — | CN | claimed |
| CN-116887809-A | Cosmetic composition for improving skin and use method thereof | 莱雅公司 | 2023-10-13 | — | — | CN | claimed |
| CN-115315293-A | Oral care compositions and methods of use | 高露洁-棕榄公司 | 2022-11-08 | — | — | CN | claimed |
| US-20200268634-A1 | EYE MAKE-UP COSMETIC COMPOSITION COMPRISING ACRYLATE-BASED COPOLYMER | COSMAX, INC. (KR) | 2020-08-27 | — | — | US | claimed |
| CN-111212629-A | Ocular cosmetic composition comprising acrylate-based copolymer | 科丝美诗株式会社 | 2020-05-29 | — | — | CN | claimed |
| US-6517823-B1 | Thickener and wax such that the gloss effect is greater than 50% | L'OREAL S.A. (FR) | 2003-02-11 | — | — | US | claimed |
| EP-1253905-A1 | HIGH GLOSS MASCARA | L'OREAL (FR) | 2002-11-06 | — | — | EP | claimed |
| WO-2001054660-A1 | HIGH GLOSS MASCARA | L'OREAL (FR) | 2001-08-02 | — | — | WO | claimed |
| US-20240207148-A1 | SPRAYABLE COMPOSITIONS CONTAINING OIL-IN-WATER EMULSIONS CONTAINING SUBMICRON HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | US | disclosed |
| WO-2024137600-A1 | SPRAYABLE COMPOSITIONS CONTAINING OIL-IN-WATER EMULSIONS CONTAINING SUBMICRON HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137409-A1 | OIL-IN-WATER EMULSIONS CONTAINING SUBMICRON HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137539-A2 | SPRAYABLE COMPOSITIONS CONTAINING OIL-IN-WATER DISPERSIONS OF HYDROPHOBIC AGENTS AND POLYMER OR COPOLYMER FRAGMENTS, OR COMBINATIONS THEREOF, AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024137719-A1 | SPRAYABLE SUNSCREEN COMPOSITIONS CONTAING OIL-IN-WATER EMULSIONS CONTAINING SUBMICRON HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF | Leading Edge Innovations, LLC (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-1999022697-A1 | PERSONAL CARE COMPOSITIONS SUITABLE FOR STYLING HAIR | THE PROCTER & GAMBLE COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1999022699-A1 | PERSONAL CARE COMPOSITIONS SUITABLE FOR APPLICATION TO THE HAIR, SKIN OR NAILS | THE PROCTER & GAMBLE COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1999022698-A1 | PERSONAL CARE COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1999022702-A1 | PERSONAL CARE COMPOSITIONS SUITABLE FOR STYLING HAIR | THE PROCTER & GAMBLE COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1998051266-A1 | FIXATIVE POLYMERS | ISP INVESTMENTS INC. (US) | 1998-11-19 | — | — | WO | disclosed |
| US-5160729-A | N-alkyl pyrrolidone surfactant; curl retention, reduced droop and drag; low volatile organic compounds | ISP INVESTMENTS INC. (US) | 1992-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240207148-A1 | SPRAYABLE COMPOSITIONS CONTAINING OIL-IN-WATER EMULSIONS CONTAINING SUBMICRON HYDROPHOBIC AGENTS AND METHODS OF USE THEREOF | LIPA, MGLL, SGMS2 | CYP2C19 2848/4885ELANE 31/4885MAPT 1884/4885 |
| US-20240207144-A1 | OIL-IN-WATER DESPERSIONS OF HYDROPHOBIC AGENTS AND POLYMER OR COPOLYMER FRAGMENTS, OR COMBINATIONS THEREOF, AND METHODS OF USE THEREOF | HTT, LIPA, PIGS | CYP2C19 3451/4885ELANE 240/4885MAPT 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.