Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 11/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649568 | 0.87 | ALDH1A1 (0.48) | ALDH1A1PYGLNPFFR2NPSR1KMT2A | |
| SCHEMBL16649545 | 0.86 | TRPA1 (0.39) | ALDH1A1 | |
| SCHEMBL12498864 | 0.86 | KCNA3 (0.37) | ALDH1A1 | |
| SCHEMBL16680947 | 0.81 | CYP1A2 (0.45) | ALDH1A1GRIK1MAPTALOX15HSD17B10 | |
| SCHEMBL15156593 | 0.77 | ALDH1A1 (0.53) | ALDH1A1PYGLNPFFR2NPSR1KMT2A | |
| SCHEMBL16649649 | 0.75 | PYGL (0.53) | ALDH1A1PYGLNPFFR2NPSR1KMT2A | |
| SCHEMBL15797909 | 0.75 | ALDH5A1 (0.45) | — | |
| SCHEMBL16649631 | 0.74 | ALDH1A1 (0.46) | ALDH1A1PYGLNPFFR2NPSR1KMT2A | |
| SCHEMBL16650004 | 0.74 | TRPA1 (0.35) | PYGLKMT2AMAPT | |
| SCHEMBL3541538 | 0.73 | CYP1A2 (0.47) | ALDH1A1NPSR1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |