SCHEMBL1665240

SCHEMBL1665240

CC(C)(CO)Cc1ccc(I)cc1[N+](=O)[O-]

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 2/20 0.40
CYP1A2 P05177 2/20 0.37
SNCA P37840 2/20 0.36
PDK3 Q15120 1/20 0.35
PDK4 Q16654 1/20 0.35
GPR35 Q9HC97 1/20 0.35
PARP1 P09874 1/20 0.35
ALOX15 P16050 1/20 0.35
ALOX12 P18054 1/20 0.35
LMNA P02545 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34
ALDH1A1 P00352 3/20 0.33
ADRB2 P07550 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1666375 0.84 CYP1A2 (0.37) PDK1CYP1A2SNCAGPR35ALOX15
SCHEMBL1665635 0.83 CYP1A2 (0.36) PDK1CYP1A2SNCAGPR35ALOX15
SCHEMBL888064 0.79 CYP1A2 (0.44) PDK1CYP1A2SNCAGPR35PARP1
SCHEMBL1667912 0.78 ALDH1A1 (0.56) CYP2C19HTTNPSR1ALDH1A1TSHR
SCHEMBL29836036 0.78 CYP1A2 (0.42) PDK1CYP1A2SNCAGPR35PARP1
SCHEMBL1665327 0.78 CYP1A2 (0.42) PDK1CYP1A2SNCAGPR35PARP1
SCHEMBL27485132 0.77 PARP1 (0.37) PDK1CYP1A2SNCAPARP1CYP3A4
SCHEMBL27770958 0.75 CYP1A2 (0.41) PDK1CYP1A2SNCAPARP1ALOX15
SCHEMBL14782199 0.75 SMN1; SMN2 (0.41) CYP1A2CYP3A4CYP2D6CYP2C19HTT
SCHEMBL1666374 0.73 ALOX15 (0.44) PDK1CYP1A2SNCAALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307565-A2 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING Lasergen, Inc. (US) 2011-04-13 EP disclosed
WO-2009152353-A2 NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING LASERGEN, INC. (US) 2009-12-17 WO disclosed