Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654340 | 0.84 | ALDH1A1 (0.54) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL16654050 | 0.84 | LMNA (0.49) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL202064 | 0.63 | RAB9A (0.61) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL8888284 | 0.63 | MCL1 (0.65) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL6325635 | 0.62 | MCL1 (1.00) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL16654083 | 0.62 | ALDH1A1 (0.52) | LMNARAB9AHPGDALDH1A1NPSR1 | |
| SCHEMBL4288841 | 0.61 | S1PR3 (0.67) | LMNARAB9AHPGDALDH1A1NPSR1 | |
| SCHEMBL12434381 | 0.61 | RAB9A (0.61) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL1486703 | 0.61 | RAB9A (0.61) | LMNAMCL1MAPTRAB9AHPGD | |
| SCHEMBL4439807 | 0.61 | RAB9A (0.61) | LMNAMCL1MAPTRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-08 | — | — | US | claimed |
| EP-3057423-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-08-24 | — | — | EP | claimed |
| WO-2015055706-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-04-23 | — | — | WO | claimed |
| US-10076116-B2 | N-cycloalkyl-N-(biheterocyclymethylene)-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-18 | — | — | US | disclosed |
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-08 | — | — | US | disclosed |
| EP-3057423-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015055706-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10076116-B2 | N-cycloalkyl-N-(biheterocyclymethylene)-(thio)carboxamide derivatives | CBR3, CYP51A1, NIT2 | LMNA 2390/4885MCL1 1796/4885MAPT 2863/4885 |
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, CYP51A1, NIT2 | LMNA 2390/4885MCL1 1796/4885MAPT 2863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.