Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1584077 | 0.98 | ADRB1 (0.54) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1663489 | 0.83 | ADRB1 (0.59) | ADRB1HTR3ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL1584087 | 0.82 | ADRB1 (0.57) | ADRB1HTR3ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8286227 | 0.81 | ADRB1 (0.52) | ADRB1SLC6A2SLC6A4SLC6A3RAB9A | |
| SCHEMBL18553759 | 0.81 | LTA4H (0.58) | SLC6A2SLC6A4SLC6A3MAPTHTR1A | |
| SCHEMBL3656969 | 0.80 | SLC6A2 (0.50) | POLBSLC6A2SLC6A4SLC6A3RAB9A | |
| SCHEMBL4396319 | 0.80 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3MAPKAPK2 | |
| SCHEMBL85663 | 0.80 | SLC6A2 (0.50) | POLBGAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13362047 | 0.79 | SLC6A2 (0.48) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13664706 | 0.79 | SLC6A2 (0.58) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339503-B2 | Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors | MERCK PATENT GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| EP-2812323-B1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| EP-2812323-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | Merck Patent GmbH (DE) | 2014-12-17 | — | — | EP | disclosed |
| WO-2013117288-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | WO | disclosed |
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2010064769-A1 | 2-PIPERAZINO-4,5-DOUBLE SUBSTITUTION-1,3-THIAZOLE DERIVATIVE AND METHOD OF PREPARING THE SAME, AND THERAPEUTIC AGENT CONTAINING THE SAME AS ITS ACTIVE INGREDIENT FOR DISEASES RELATED TO INFLAMMATION CAUSED BY SPC RECEPTOR ACTIVITY | 한국화학연구원 (KR) | 2010-06-10 | — | — | WO | disclosed |
| EP-0126480-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES, METHOD FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | TNKS, PARP1, PARP11 | ADRB1 2900/4885HTR3E 1233/4885HTR3B 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.