Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017170 | 0.83 | EDNRB (0.37) | EDNRBEDNRAPLCG1L3MBTL1CA1 | |
| SCHEMBL27488000 | 0.80 | EDNRB (0.35) | EDNRBEDNRAPLCG1L3MBTL1CA1 | |
| SCHEMBL1272338 | 0.75 | PTGS2 (0.41) | PTGS1PTGS2 | |
| SCHEMBL30488778 | 0.75 | PTGS2 (0.41) | PTGS1PTGS2 | |
| SCHEMBL4157506 | 0.74 | LMNA (0.47) | EDNRBEDNRACA2ALDH1A1HSP90AA1 | |
| SCHEMBL5174336 | 0.72 | L3MBTL1 (0.39) | EDNRBEDNRAL3MBTL1CA1CA2 | |
| SCHEMBL15746567 | 0.71 | KMT2A (0.34) | L3MBTL1ALDH1A1 | |
| SCHEMBL23148806 | 0.71 | TSHR (0.53) | ALDH1A1 | |
| SCHEMBL30019925 | 0.71 | TSHR (0.53) | ALDH1A1 | |
| SCHEMBL15009785 | 0.70 | ALOX5AP (0.43) | L3MBTL1ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012443-B2 | Bicyclic aryl and heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |