Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670210 | 0.81 | MAPT (0.36) | HIF1AEPAS1MAPTKDM4EALDH1A1 | |
| SCHEMBL31643652 | 0.78 | MAPT (0.51) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL17574341 | 0.78 | MAPT (0.62) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL10088414 | 0.78 | ERN1 (0.44) | BACE1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7861678 | 0.77 | HIF1A (0.55) | HIF1AEPAS1MAPTKDM4EALDH1A1 | |
| SCHEMBL3221392 | 0.76 | MAPT (0.47) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL23041032 | 0.76 | LMNA (0.59) | BACE1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL15287726 | 0.75 | PTPN1 (0.39) | MAPTKDM4EALDH1A1LMNATP53 | |
| SCHEMBL17559171 | 0.75 | MAPT (0.39) | BACE1MAPTHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL16242750 | 0.75 | GRM2 (0.48) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861572-B1 | IMPROVED PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES | NATCO PHARMA LTD (IN) | 2018-10-31 | — | — | EP | disclosed |
| US-9227948-B2 | Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives | NATCO PHARMA LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-9227948-B2 | Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives | NATCO PHARMA LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-9227948-B2 | Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives | NATCO PHARMA LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-20150119587-A1 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES | NATCO PHARMA LIMITED (IN) | 2015-04-30 | — | — | US | disclosed |
| US-20150119587-A1 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES | NATCO PHARMA LIMITED (IN) | 2015-04-30 | — | — | US | disclosed |
| US-20150119587-A1 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES | NATCO PHARMA LIMITED (IN) | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119587-A1 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-2-(6-(SUBSTITUTED)-7-METHYLBENZO[D][1,3]DIOXOL-4-YL)ACETIC ACID DERIVATIVES | DERA, XDH, F12 | BACE1 3575/4885HIF1A 438/4885EPAS1 1992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.