Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551523 | 0.81 | BACE1 (0.51) | BACE1HDAC8PTPN1TAS1R3TAS1R1 | |
| SCHEMBL28034772 | 0.78 | MEN1 (0.42) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL27773458 | 0.77 | POLB (0.50) | BACE1HDAC8PTPN1TAS1R3TAS1R1 | |
| SCHEMBL13952366 | 0.77 | PTGDR2 (0.43) | BACE1ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7062417 | 0.77 | BACE1 (0.48) | BACE1HDAC8PTPN1TAS1R3TAS1R1 | |
| SCHEMBL584252 | 0.76 | APLNR (0.59) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3312341 | 0.76 | KMT2A (0.45) | ALDH1A1HPGDHTTKMT2AMEN1 | |
| SCHEMBL31708810 | 0.76 | PTPN1 (0.46) | BACE1HDAC8PTPN1TAS1R3TAS1R1 | |
| SCHEMBL4234360 | 0.76 | DPP4 (0.50) | HDAC3HDAC1KMT2A | |
| SCHEMBL910548 | 0.75 | POLB (0.62) | ALDH1A1HPGDNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139543-B2 | Thiazole compounds and uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-09-22 | — | — | US | disclosed |
| US-20150119430-A1 | Thiazole Compounds and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119430-A1 | Thiazole Compounds and Uses Thereof | BAX, TNNT2, TNNI3 | BACE1 1899/4885HDAC8 770/4885PTPN1 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.