Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667203 | 1.00 | KDM4E (0.41) | KDM4ENAPRTHCAR2FFAR1GPR88 | |
| SCHEMBL31076264 | 1.00 | KDM4E (0.41) | KDM4ENAPRTHCAR2FFAR1GPR88 | |
| Hydrochloric Acid SCHEMBL2521888 | 0.98 | KDM4E (0.40) | KDM4ENAPRTHCAR2FFAR1GPR88 | |
| Hydrochloric Acid SCHEMBL2521887 | 0.98 | KDM4E (0.40) | KDM4ENAPRTHCAR2FFAR1GPR88 | |
| SCHEMBL31355232 | 0.84 | ADORA3 (0.43) | KDM4ENAPRTHCAR2GPR88ADORA3 | |
| SCHEMBL23543046 | 0.75 | FFAR1 (0.42) | FFAR1CYP2C8 | |
| SCHEMBL3596616 | 0.75 | RIPK1 (0.48) | NAPRTFFAR1GPR88NR4A2RXRA | |
| SCHEMBL1207556 | 0.75 | RIPK1 (0.48) | NAPRTFFAR1GPR88NR4A2RXRA | |
| SCHEMBL22503549 | 0.75 | FFAR1 (0.42) | FFAR1CYP2C8 | |
| SCHEMBL13167851 | 0.75 | RIPK1 (0.48) | NAPRTFFAR1GPR88NR4A2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486014-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-31 | — | — | EP | disclosed |
| US-8426414-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2486014-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | Bristol-Myers Squibb Company and Lexicon Pharmaceuticals, Inc. | 2011-10-13 | — | — | US | disclosed |
| WO-2011044212-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | GPR88, GPR68, GRK2 | KDM4E 3626/4885NAPRT 2961/4885HCAR2 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.