SCHEMBL16675402

SCHEMBL16675402

CC(C)(C)C1=CC(=Nc2ccc(N=C3C=C(C(C)(C)C)C(=O)C(C(C)(C)C)=C3)cc2)C=C(C(C)(C)C)C1=O

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.57
ATM Q13315 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
CES2 O00748 1/20 0.41
PKM P14618 1/20 0.41
HPGD P15428 1/20 0.41
CES1 P23141 1/20 0.41
MPI P34949 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
MCL1 Q07820 1/20 0.39
NPC1 O15118 1/20 0.35
KMT2A Q03164 1/20 0.35
GPR35 Q9HC97 1/20 0.35
POLB P06746 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2814567 0.91 SMN1; SMN2 (0.50) SMN1; SMN2ATMALDH1A1MAPTCES2
SCHEMBL1814868 0.90 SMN1; SMN2 (0.61) SMN1; SMN2ATMALDH1A1MAPTCES2
SCHEMBL9490926 0.88 SMN1; SMN2 (0.48) SMN1; SMN2ALDH1A1MAPTHPGDMPI
SCHEMBL8971624 0.83 SMN1; SMN2 (0.43) SMN1; SMN2ATMALDH1A1MAPTCES2
SCHEMBL12103681 0.81 SMN1; SMN2 (0.44) SMN1; SMN2ALDH1A1MAPTNPSR1KMT2A
SCHEMBL8971203 0.81 RXRA (0.45) SMN1; SMN2ALDH1A1NPSR1
SCHEMBL8971980 0.81 SMN1; SMN2 (0.42) SMN1; SMN2ATMALDH1A1MAPTPKM
SCHEMBL8971390 0.78 SMN1; SMN2 (0.49) SMN1; SMN2ATMALDH1A1MAPTCES2
SCHEMBL10364440 0.78 MAPT (0.55) SMN1; SMN2ALDH1A1MAPTPKMKMT2A
SCHEMBL9490497 0.76 MEN1 (0.39) SMN1; SMN2ATMALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9933712-B2 Multi-layer electrophotographic photosensitive member, process cartridge, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2018-04-03 US disclosed
US-9933712-B2 Multi-layer electrophotographic photosensitive member, process cartridge, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2018-04-03 US disclosed
US-20170060006-A1 MULTI-LAYER ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-03-02 US disclosed
US-20170060006-A1 MULTI-LAYER ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-03-02 US disclosed
EP-3136175-A1 MULTI-LAYER ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR PRODUCING THE SAME, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS Kyocera Document Solutions Inc. (JP) 2017-03-01 EP disclosed
US-20150118608-A1 MULTI-LAYER ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-04-30 US disclosed
US-20150118608-A1 MULTI-LAYER ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-04-30 US disclosed