Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666992 | 0.81 | ALDH1A1 (0.46) | HPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1666291 | 0.80 | HPGD (0.52) | HPGDLMNACTSDALDH1A1L3MBTL1 | |
| SCHEMBL15099937 | 0.80 | HPGD (0.52) | HPGDLMNACTSDALDH1A1L3MBTL1 | |
| SCHEMBL1666294 | 0.80 | HPGD (0.52) | HPGDLMNACTSDALDH1A1L3MBTL1 | |
| SCHEMBL12986958 | 0.72 | ALDH1A1 (0.49) | HPGDLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9268117 | 0.72 | HPGD (0.62) | HPGDLMNACTSDALDH1A1HTT | |
| SCHEMBL22447716 | 0.71 | DRD2 (0.44) | HPGDKDM4E | |
| SCHEMBL13753006 | 0.71 | CTSD (0.68) | HPGDLMNACTSDALDH1A1L3MBTL1 | |
| SCHEMBL8117817 | 0.71 | CTSD (0.68) | HPGDLMNACTSDALDH1A1L3MBTL1 | |
| SCHEMBL13162537 | 0.71 | ALDH1A1 (0.53) | HPGDCTSDALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485728-A1 | WNT PATHWAY ANTAGONISTS | Siena Biotech S.p.a. (IT) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042145-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2011-04-14 | — | — | WO | disclosed |