Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535647 | 0.81 | DRD2 (0.47) | ALDH1A1HPGDKDM4ERCE1DRD2 | |
| SCHEMBL15534816 | 0.81 | P2RX7 (0.47) | DRD2HTR3EHTR3BHTR3AHTR4 | |
| SCHEMBL22447716 | 0.81 | DRD2 (0.44) | HPGDKDM4EDRD2HTR3EHTR3B | |
| SCHEMBL1668136 | 0.81 | HPGD (0.50) | ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL15534876 | 0.79 | DRD2 (0.38) | ALDH1A1HPGDKDM4ESLC6A2SLC6A4 | |
| SCHEMBL1668907 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ERCE1USP2 | |
| SCHEMBL12798265 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ERCE1USP2 | |
| SCHEMBL1666506 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ERCE1USP2 | |
| SCHEMBL11893819 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ERCE1USP2 | |
| SCHEMBL1666286 | 0.77 | SLC6A2 (0.40) | ALDH1A1HPGDKDM4ESLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485728-A1 | WNT PATHWAY ANTAGONISTS | Siena Biotech S.p.a. (IT) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042145-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2011-04-14 | — | — | WO | disclosed |