Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PLG | P00747 | 1/20 | 0.57 |
| ▸ | PLAT | P00750 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.50 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893729 | 1.00 | LMNA (0.57) | LMNAPLGPLATALDH1A1HPGD | |
| SCHEMBL102680 | 0.92 | HPGD (0.54) | LMNAPLGPLATALDH1A1HPGD | |
| SCHEMBL15398791 | 0.91 | LMNA (0.48) | LMNAPLGPLATALDH1A1HPGD | |
| SCHEMBL11893711 | 0.87 | LMNA (0.44) | LMNAPLGPLATALDH1A1HPGD | |
| SCHEMBL11893712 | 0.87 | LMNA (0.44) | LMNAPLGPLATALDH1A1HPGD | |
| SCHEMBL7420226 | 0.83 | TPSAB1 (0.66) | ALDH1A1HPGDTSHRTP53 | |
| SCHEMBL17551490 | 0.82 | ALDH1A1 (0.64) | LMNAALDH1A1HPGDTSHRTP53 | |
| SCHEMBL2956853 | 0.82 | — | — | |
| SCHEMBL19569940 | 0.82 | ALDH1A1 (0.75) | LMNAALDH1A1HPGDTSHRTP53 | |
| SCHEMBL6085 | 0.80 | HPGD (0.45) | LMNAPLGPLATALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865704-B2 | Wnt pathway antagonists | SIENA BIOTECH S.P.A. (IT) | 2014-10-21 | — | — | US | disclosed |
| EP-2485728-B1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH SPA (IT) | 2013-07-10 | — | — | EP | disclosed |
| EP-2485728-A1 | WNT PATHWAY ANTAGONISTS | Siena Biotech S.p.a. (IT) | 2012-08-15 | — | — | EP | disclosed |
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
| WO-2011042145-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | WNT1, WNT3A, CTNNB1 | LMNA 3034/4885PLG 3898/4885PLAT 3846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.