Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293002 | 0.77 | PDE10A (0.36) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL1265708 | 0.75 | ROCK1 (0.50) | MAPTLMNAHSP90AA1 | |
| SCHEMBL28033503 | 0.75 | PDE10A (0.35) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL251217 | 0.75 | SOS1 (0.37) | PIN1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12777859 | 0.75 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2APDE10A | |
| SCHEMBL537339 | 0.75 | MAPT (0.39) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL21426310 | 0.74 | PIN1 (0.37) | PIN1MEN1KMT2AMAPTLMNA | |
| SCHEMBL826540 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL29736537 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL2369694 | 0.71 | PIK3CA (0.57) | MEN1KMT2ATDP1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844064-B2 | sGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-10668051-B2 | Modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS SA (CH) | 2020-06-02 | — | — | US | disclosed |
| US-10414768-B2 | Compounds for treating cystic fibrosis | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-09-17 | — | — | US | disclosed |
| CN-110078741-A | Ring-fused pyrimidines An base Yan Sheng Wu ﹑ preparation method, intermediate, pharmaceutical composition and application | 广州再极医药科技有限公司 | 2019-08-02 | — | — | CN | disclosed |
| US-10344017-B2 | Pyrrolcarboxamide derivatives for the inhibition of ERK5 | CANCER RESEARCH TECH LTD (GB) | 2019-07-09 | — | — | US | disclosed |
| US-20190160046-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS AG (CH) | 2019-05-30 | — | — | US | disclosed |
| CN-109748885-A | A kind of preparation method of Ceritinib intermediate and Ceritinib | 新发药业有限公司 | 2019-05-14 | — | — | CN | disclosed |
| US-10246450-B2 | Modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS SA (CH) | 2019-04-02 | — | — | US | disclosed |
| US-20180222898-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS AG (CH) | 2018-08-09 | — | — | US | disclosed |
| US-20180170911-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHIBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-06-21 | — | — | US | disclosed |
| EP-0138995-B1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | South Alabama Medical Science Foundation (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0283742-A2 | Fatty acid amides as inhibitors of acyl-CoA: cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4743605-A | PREVENT ABSORPTION OF CHOLESTEROL | WARNER-LAMBERT COMPANY (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0138995-A4 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1988-05-10 | — | — | EP | disclosed |
| US-4716175-A | INHIBITION OF INTESTINAL ABSORPTION OF CHOLESTEROL | WARNER-LAMBERT COMPANY (US) | 1987-12-29 | — | — | US | disclosed |
| EP-0138995-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. | UNIV SOUTH ALABAMA (US) | 1985-05-02 | — | — | EP | disclosed |
| EP-0039037-B1 | PYRIMIDYLTHIO-UREAS, MEDICINES CONTAINING THEM AND THEIR USE | Beiersdorf Aktiengesellschaft (DE) | 1985-01-16 | — | — | EP | disclosed |
| WO-1984004040-A1 | REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES | UNIV SOUTH ALABAMA (US) | 1984-10-25 | — | — | WO | disclosed |
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |
| EP-0039037-A1 | Pyrimidylthio-ureas, medicines containing them and their use | Beiersdorf Aktiengesellschaft (DE) | 1981-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10668051-B2 | Modulators of calcium release-activated calcium channel | ORAI1, CACNB2, CACNB1 | PIN1 4706/4885ALDH1A1 3752/4885KDM4E 3583/4885 |
| US-20180170911-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHIBITION OF ERK5 | MAPKAPK5, MAP3K5, MAPK15 | PIN1 175/4885ALDH1A1 2159/4885KDM4E 1866/4885 |
| US-10414768-B2 | Compounds for treating cystic fibrosis | CFTR, ABCB11, SLC26A4 | PIN1 985/4885ALDH1A1 186/4885KDM4E 2899/4885 |
| US-20190160046-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | ORAI1, CACNB2, CACNA1E | PIN1 4625/4885ALDH1A1 3912/4885KDM4E 3486/4885 |
| US-10844064-B2 | sGC stimulators | GUCY1B1, GUCY1A1, PRKG1 | PIN1 4878/4885ALDH1A1 1902/4885KDM4E 911/4885 |
| US-20180222898-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | ORAI1, CACNB2, CACNA1E | PIN1 4625/4885ALDH1A1 3912/4885KDM4E 3486/4885 |
| US-10246450-B2 | Modulators of calcium release-activated calcium channel | ORAI1, CACNB2, CACNB1 | PIN1 4706/4885ALDH1A1 3752/4885KDM4E 3583/4885 |
| US-10344017-B2 | Pyrrolcarboxamide derivatives for the inhibition of ERK5 | MAPKAPK5, MAP3K5, MAPK15 | PIN1 175/4885ALDH1A1 2159/4885KDM4E 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.