Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16499510 | 0.80 | FFAR1 (0.39) | OPRM1IGF1RALOX15ALOX5AP | |
| SCHEMBL12800418 | 0.78 | OPRM1 (0.40) | OPRM1HTR2ATACR1AKT2 | |
| SCHEMBL1669451 | 0.76 | ALDH1A1 (0.47) | OPRM1HTR2ATACR1TSHRALDH1A1 | |
| SCHEMBL1669123 | 0.74 | OPRD1 (0.51) | OPRM1ALOX15TACR1TSHR | |
| SCHEMBL16498996 | 0.72 | OPRM1 (0.44) | OPRM1IGF1RALOX15BACE1 | |
| SCHEMBL16499375 | 0.72 | CYP2D6 (0.56) | OPRM1TACR1BACE1KDM4EALDH1A1 | |
| SCHEMBL16499514 | 0.70 | DRD4 (0.42) | OPRM1IGF1RALOX15TSHRKDM4E | |
| SCHEMBL16511876 | 0.69 | DRD4 (0.47) | OPRM1ALOX15TSHRBACE1KDM4E | |
| Hydrocinnamyl Alcohol SCHEMBL27345407 | 0.69 | SIGMAR1 (0.55) | MAPTLTA4HEPHX2 | |
| SCHEMBL1669606 | 0.68 | CA12 (0.47) | OPRM1HTR2AALOX15TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011154678-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011154678-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |