Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720197 | 0.79 | SMN1; SMN2 (0.38) | DYRK1ADYRK1BCLK4 | |
| SCHEMBL4276321 | 0.78 | PDE10A (0.43) | PDK2POLQMKNK2TDO2 | |
| SCHEMBL9180615 | 0.76 | ACHE (0.40) | DYRK1APIM1DYRK1BCDK8MAP4K4 | |
| SCHEMBL11919644 | 0.74 | WNT3A (0.54) | DYRK1APIM1DYRK2DYRK1BS1PR1 | |
| SCHEMBL7453756 | 0.74 | CLK4 (0.40) | DYRK1ABRD4CLK4 | |
| SCHEMBL9151380 | 0.74 | ACHE (0.35) | — | |
| SCHEMBL3535486 | 0.73 | ALDH1A1 (0.39) | — | |
| SCHEMBL6844999 | 0.73 | DYRK1A (0.51) | DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL5779607 | 0.73 | CYP1A1 (0.45) | DYRK1ABRD4CLK4TDO2 | |
| SCHEMBL9330420 | 0.72 | ABL1 (0.53) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |