Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535486 | 0.83 | ALDH1A1 (0.39) | SMN1; SMN2RAB9ATP53NPC1GAA | |
| SCHEMBL7953803 | 0.81 | MKNK1 (0.46) | SMN1; SMN2RAB9ANPC1CYP11B1CYP11B2 | |
| SCHEMBL9151380 | 0.80 | ACHE (0.35) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL1646811 | 0.80 | ABL1 (0.50) | SMN1; SMN2RAB9ATP53NPC1CLK4 | |
| SCHEMBL16686010 | 0.79 | DYRK1A (0.47) | DYRK1ACLK4DYRK1B | |
| SCHEMBL17514813 | 0.79 | SLC6A4 (0.42) | SQOR | |
| SCHEMBL28140406 | 0.79 | ABL1 (0.49) | GAA | |
| SCHEMBL6985969 | 0.79 | SLC6A4 (0.42) | RAB9ANPC1SQORDYRK1AMAPT | |
| SCHEMBL1490970 | 0.79 | SLC6A3 (0.41) | SMN1; SMN2RAB9ATP53NPC1MAPT | |
| SCHEMBL16720564 | 0.78 | NOTUM (0.39) | SMN1; SMN2MAPTNOTUMCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |