Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terbutaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | CASP7 | P55210 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | APEX1 | P27695 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Colterol SCHEMBL3220142 | 0.86 | ADRB2 (0.72) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Colterol SCHEMBL3207818 | 0.86 | ADRB2 (0.72) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Colterol SCHEMBL249585 | 0.86 | ADRB2 (0.72) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL1417928 | 0.86 | ADRB2 (0.70) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL4391 | 0.82 | LMNA (1.00) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL13327959 | 0.82 | LMNA (1.00) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL41869 | 0.82 | LMNA (1.00) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Albuterol SCHEMBL328959 | 0.81 | ADRB2 (0.87) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL8761821 | 0.80 | BLM (0.67) | ADRB2KMT2AHIF1ALMNACYP3A4 | |
| Terbutaline SCHEMBL404480 | 0.80 | ADRB2 (0.96) | ADRB2KMT2AHIF1ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693883-A1 | SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | Cornell University (US) | 2014-02-12 | — | — | EP | disclosed |
| EP-2694707-A1 | MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | Cornell University (US) | 2014-02-12 | — | — | EP | disclosed |
| WO-2013058825-A1 | SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | CORNELL UNIVERSITY (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2013058824-A1 | MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | CORNELL UNIVERSITY (US) | 2013-04-25 | — | — | WO | disclosed |
| EP-2485678-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | Cornell University (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011043817-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | WO | disclosed |