Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.60 |
| ▸ | MPI | P34949 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16696526 | 0.82 | P4HB (0.80) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL15741399 | 0.82 | P4HB (0.66) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL1700908 | 0.81 | P4HB (0.98) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL31023808 | 0.79 | MGLL (0.55) | ALDH1A1MAPTKMT2AHTTMEN1 | |
| SCHEMBL11895967 | 0.78 | P4HB (0.80) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL1240268 | 0.74 | P4HB (0.69) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL31023653 | 0.74 | OPRD1 (0.51) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL1240900 | 0.73 | ALDH1A1 (0.74) | P4HBALDH1A1ALOX12KDM4EMAPT | |
| SCHEMBL31023688 | 0.73 | MGLL (0.55) | ALDH1A1MAPTLMNACYP3A4CYP3A5 | |
| SCHEMBL16696588 | 0.72 | KMT2A (0.80) | P4HBALDH1A1ALOX12KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133450-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | EUTROPICS PHARMACEUTICALS INC (US) | 2015-05-14 | — | — | US | claimed |
| US-20150133450-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | EUTROPICS PHARMACEUTICALS INC (US) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133450-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | BCL3, BCL6, MCL1 | P4HB 2154/4885ALDH1A1 4177/4885ALOX12 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.