SCHEMBL1700908

SCHEMBL1700908

Oc1c(C(c2ccc(F)cc2)N2CCCC2)ccc2cccnc12

nearest known ligand 0.98

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HB P07237 10/20 0.98
KMT2A Q03164 3/20 0.65
HSP90AA1 P07900 3/20 0.65
ALDH1A1 P00352 3/20 0.65
HTT P42858 3/20 0.65
KDM4E B2RXH2 2/20 0.65
MAPT P10636 2/20 0.65
SMN1; SMN2 Q16637 2/20 0.65
S1PR4 O95977 1/20 0.65
S1PR1 P21453 1/20 0.65
AGTR1 P30556 1/20 0.65
NPSR1 Q6W5P4 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
BRAF P15056 1/20 0.61
ATM Q13315 1/20 0.60
TP53 P04637 2/20 0.58
ALOX15 P16050 2/20 0.58
ALOX12 P18054 2/20 0.58
MEN1 O00255 1/20 0.58
MAPK1 P28482 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16696526 0.90 P4HB (0.80) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL11895967 0.90 P4HB (0.80) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL16696547 0.87 P4HB (0.79) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL14652565 0.87 P4HB (0.79) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL30868623 0.86 P4HB (0.78) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL25079458 0.83 P4HB (0.70) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL30253871 0.83 P4HB (0.70) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL1240268 0.82 P4HB (0.69) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL14680236 0.82 P4HB (0.69) P4HBKMT2AHSP90AA1ALDH1A1HTT
SCHEMBL16696541 0.81 P4HB (0.66) P4HBKMT2AHSP90AA1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130131096-A1 8-HYDROXY-QUINOLINE DERIVATIVES UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) 2013-05-23 US claimed
CN-102985407-A 8-hydroxy-quinoline derivatives AVIDIN KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG 2013-03-20 CN claimed
EP-2566849-B1 8-HYDROXY-QUINOLINE DERIVATIVES AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) 2019-09-18 EP disclosed
EP-2566849-B1 8-HYDROXY-QUINOLINE DERIVATIVES AVIDIN KUTATO FEJLESZTOE ES KERESKEDELMI KORLATOLT FELELOESSEGUE TARSASAG (HU) 2019-09-18 EP disclosed
CN-102985407-B 8-hydroxy-quinoline derivatives "AVIDIN" KUTATO, FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG (HU) 2015-09-09 CN disclosed
US-8871937-B2 8-hydroxy-quinoline derivatives “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) 2014-10-28 US disclosed
US-8871937-B2 8-hydroxy-quinoline derivatives “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) 2014-10-28 US disclosed
US-8871937-B2 8-hydroxy-quinoline derivatives “AVIDIN” Kutato, Fejleszto es Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) 2014-10-28 US disclosed
US-20130131096-A1 8-HYDROXY-QUINOLINE DERIVATIVES UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) 2013-05-23 US disclosed
US-20130131096-A1 8-HYDROXY-QUINOLINE DERIVATIVES UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) 2013-05-23 US disclosed
US-20130131096-A1 8-HYDROXY-QUINOLINE DERIVATIVES UBICHEM KUTATO KORLATOLT FELELOSSEGU TARSASAG (HU) 2013-05-23 US disclosed
CN-102985407-A 8-hydroxy-quinoline derivatives AVIDIN KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG 2013-03-20 CN disclosed
EP-2566849-A1 8-HYDROXY-QUINOLINE DERIVATIVES "Avidin" Kutató, Fejleszt És Kereskedelmi Korlatolt Felelossegu Tarsasag (HU) 2013-03-13 EP disclosed
WO-2011148208-A1 8-HYDROXY-QUINOLINE DERIVATIVES "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) 2011-12-01 WO disclosed
WO-2011148208-A1 8-HYDROXY-QUINOLINE DERIVATIVES "AVIDIN" KUTATÓ, FEJLESZTŐ ÉS KERESKEDELMI KORLÁTOLT FELELŐSSÉGŰ TÁRSASÁG (HU) 2011-12-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131096-A1 8-HYDROXY-QUINOLINE DERIVATIVES CYP2C8, NQO1, KEAP1 P4HB 1817/4885KMT2A 3307/4885HSP90AA1 3406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.