Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29179298 | 0.88 | MET (0.42) | METNQO2NR1H4CPT2CPT1A | |
| SCHEMBL2999873 | 0.88 | GPR119 (0.54) | CYP4F2CYP4A11KDM4E | |
| SCHEMBL13274935 | 0.84 | HRH3 (0.43) | METNQO2F2PDE4D | |
| SCHEMBL1296781 | 0.82 | GPR119 (0.41) | METNQO2NR1H4CPT2CPT1A | |
| SCHEMBL28616820 | 0.80 | RBP4 (0.46) | NR1H4F2 | |
| SCHEMBL15679415 | 0.79 | NR1H4 (0.41) | METNQO2NR1H4PDE4DGABRG2 | |
| SCHEMBL23344107 | 0.79 | MET (0.54) | METNQO2NR1H4ALDH1A1 | |
| SCHEMBL631819 | 0.79 | DRD2 (0.52) | CYP4F2CYP4A11KDM4EALDH1A1CYP3A4 | |
| SCHEMBL22309794 | 0.77 | GPR119 (0.54) | KDM4E | |
| SCHEMBL19400195 | 0.76 | CYP4F2 (0.49) | CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403799-B2 | Pyrimidinyl-pyridazinone derivatives for treating a disease which is influenced by inhibition of met kinase | MERCK PATENT GMBH (DE) | 2016-08-02 | — | — | US | disclosed |
| US-20150133452-A1 | PYRIMIDINYL PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133452-A1 | PYRIMIDINYL PYRIDAZINONE DERIVATIVES | MET, MERTK, ABL1 | MET 1/4885NQO2 1075/4885NR1H4 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.