Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16539832 | 0.85 | HTR2C (0.43) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6649033 | 0.82 | HTR2C (0.40) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8707482 | 0.74 | HTR2C (0.38) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6544398 | 0.74 | NPC1 (0.51) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL7565105 | 0.73 | NPC1 (0.50) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28648250 | 0.73 | CTRB1 (0.48) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL27193408 | 0.70 | HTR2C (0.51) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL14713128 | 0.70 | SIGMAR1 (0.36) | HTR2CKDM1A | |
| SCHEMBL7711512 | 0.70 | ENPP2 (0.54) | HTR2CNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL2801668 | 0.69 | NOTUM (0.40) | MAPK1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015028960-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-03-05 | — | — | WO | disclosed |
| EP-2488500-A1 | SPIROPIPERIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF FOR TREATING DIABETES | Eli Lilly and Company (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046851-A1 | SPIROPIPERIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF FOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 2011-04-21 | — | — | WO | disclosed |