Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 12/20 | 0.83 |
| ▸ | HSPA1A | P0DMV8 | 9/20 | 0.68 |
| ▸ | POLB | P06746 | 6/20 | 0.68 |
| ▸ | GAPDH | P04406 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | HSPA8 | P11142 | 4/20 | 0.68 |
| ▸ | RECQL | P46063 | 4/20 | 0.68 |
| ▸ | BLM | P54132 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | DUSP1 | P28562 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856742 | 0.81 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL2117400 | 0.81 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL16706088 | 0.74 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL13056428 | 0.74 | NR4A1 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL2116061 | 0.71 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL16325985 | 0.71 | NR4A1 (0.70) | TDP1PTPN7HSPA1APOLBMEN1 | |
| SCHEMBL16706090 | 0.71 | MEN1 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL13856208 | 0.71 | NR4A1 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL14680373 | 0.70 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH | |
| SCHEMBL2116528 | 0.70 | PTPN7 (1.00) | TDP1PTPN7HSPA1APOLBGAPDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-03-26 | — | — | US | disclosed |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-9730941-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730941-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | PIN1, AS3MT, PML | TDP1 1880/4885PTPN7 161/4885HSPA1A 1541/4885 |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | TDP1 2798/4885PTPN7 589/4885HSPA1A 976/4885 |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | PIN1, AS3MT, PML | TDP1 1880/4885PTPN7 161/4885HSPA1A 1541/4885 |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | TDP1 2798/4885PTPN7 589/4885HSPA1A 976/4885 |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | TDP1 2798/4885PTPN7 589/4885HSPA1A 976/4885 |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | PIN1, FKBP1A, FKBP2 | TDP1 2798/4885PTPN7 589/4885HSPA1A 976/4885 |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | PIN1, FKBP1A, FKBP2 | TDP1 2798/4885PTPN7 589/4885HSPA1A 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.