Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | POLB | P06746 | 6/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 10/20 | 0.65 |
| ▸ | HSPA1A | P0DMV8 | 7/20 | 0.65 |
| ▸ | HSPA8 | P11142 | 5/20 | 0.65 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | GAPDH | P04406 | 5/20 | 0.53 |
| ▸ | BLM | P54132 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23949485 | 0.79 | PTPN7 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL16706088 | 0.75 | PTPN7 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL13056428 | 0.72 | NR4A1 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL16706089 | 0.71 | TDP1 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL13725379 | 0.70 | HSPA1A (0.62) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL13056448 | 0.69 | PTPN7 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL6087749 | 0.69 | HSPA1A (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL16706085 | 0.68 | PTPN7 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL14680373 | 0.67 | PTPN7 (1.00) | MEN1KMT2APOLBPTPN7HSPA1A | |
| SCHEMBL13725224 | 0.67 | PTPN7 (0.63) | MEN1KMT2APOLBPTPN7HSPA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-03-26 | — | — | US | disclosed |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-9730941-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730941-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | PIN1, AS3MT, PML | MEN1 3503/4885KMT2A 1979/4885POLB 2449/4885 |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | MEN1 4156/4885KMT2A 3006/4885POLB 1852/4885 |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | PIN1, AS3MT, PML | MEN1 3503/4885KMT2A 1979/4885POLB 2449/4885 |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | MEN1 4156/4885KMT2A 3006/4885POLB 1852/4885 |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | MEN1 4156/4885KMT2A 3006/4885POLB 1852/4885 |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | PIN1, FKBP1A, FKBP2 | MEN1 4156/4885KMT2A 3006/4885POLB 1852/4885 |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | PIN1, FKBP1A, FKBP2 | MEN1 4156/4885KMT2A 3006/4885POLB 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.