Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 13/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 3/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670817 | 0.86 | MLYCD (0.40) | BRD4CREBBPBRD2 | |
| SCHEMBL12800374 | 0.82 | PTGS2 (0.50) | PTGS2BRD4BRD2BRD3 | |
| SCHEMBL1670709 | 0.81 | PTGS2 (0.48) | PTGS2BRD4CREBBPBRD2BRD3 | |
| SCHEMBL12800444 | 0.80 | BRD4 (0.47) | PTGS2BRD4BRD2BRD3 | |
| SCHEMBL17833811 | 0.75 | PTGS2 (0.72) | PTGS2BRD4BRD2BRD3 | |
| SCHEMBL1671716 | 0.74 | GRIA2 (0.41) | NPSR1 | |
| SCHEMBL1672841 | 0.70 | MAOA (0.39) | PTGS2BRD4CREBBPBRD2BRD3 | |
| SCHEMBL1670795 | 0.70 | AR (0.44) | BRD4CREBBPBRD2NPSR1 | |
| SCHEMBL12800381 | 0.69 | PTGS2 (0.51) | PTGS2BRD4BRD2BRD3 | |
| SCHEMBL12800382 | 0.68 | MLYCD (0.42) | BRD4CREBBPBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |