Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.57 |
| ▸ | RORC | P51449 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.57 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | POLA1 | P09884 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CDC25A | P30304 | 2/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | CRYAB | P02511 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27507701 | 1.00 | OSBP (0.57) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL27507702 | 1.00 | OSBP (0.57) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL8336472 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL8336467 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL6388729 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL6387062 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL6391972 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL6387555 | 0.88 | RORC (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL24264118 | 0.83 | USP2 (0.74) | OSBPRORCUSP2CYP46A1OSBP2 | |
| SCHEMBL14052247 | 0.83 | USP2 (0.74) | OSBPRORCUSP2CYP46A1OSBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230066056-A1 | METHODS AND USES FOR PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) INHIBITORS | ANJI PHARMACEUTICALS INC. | 2023-03-02 | — | — | US | disclosed |
| US-10570157-B2 | Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors | THE UNIVERSITY OF MANCHESTER (GB) | 2020-02-25 | — | — | US | disclosed |
| US-20180215772-A1 | CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS | THE UNIVERSITY OF MANCHESTER (GB) | 2018-08-02 | — | — | US | disclosed |
| EP-3328868-A1 | CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS | The University of Manchester (GB) | 2018-06-06 | — | — | EP | disclosed |
| EP-2849788-B1 | PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) INHIBITORS FOR USE IN TREATING SEPSIS AND SEPTIC SHOCK | CYON THERAPEUTICS INC (CA) | 2018-01-03 | — | — | EP | disclosed |
| WO-2017017469-A1 | CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS | THE UNIVERSITY OF MANCHESTER (GB) | 2017-02-02 | — | — | WO | disclosed |
| US-20150140005-A1 | Methods and Uses for Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors | ANJI PHARMACEUTICALS INC. (KY) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570157-B2 | Cyclic diarylboron derivatives as NLRP3 inflammasome inhibitors | NLRP3, IL1B, NOD1 | OSBP 703/4885RORC 86/4885USP2 1950/4885 |
| US-20180215772-A1 | CYCLIC DIARYLBORON DERIVATIVES AS NLRP3 INFLAMMASOME INHIBITORS | NLRP3, IL1B, NOD1 | OSBP 703/4885RORC 86/4885USP2 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.