Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18094573 | 0.90 | ADORA3 (0.53) | HTTKMT2AALDH1A1ADORA3MAPT | |
| SCHEMBL18094472 | 0.90 | MPL (0.42) | HTTKDM4EKMT2AADORA3MAPT | |
| SCHEMBL18094540 | 0.89 | MAPT (0.43) | ADORA3MAPTTP53MPLSMN1; SMN2 | |
| SCHEMBL18094510 | 0.85 | HTR2A (0.48) | — | |
| SCHEMBL18094473 | 0.84 | KDM4E (0.45) | KDM4EADORA3MAPTTP53MPL | |
| SCHEMBL16718882 | 0.83 | MPL (0.51) | HTTKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL18094557 | 0.83 | MAPT (0.53) | ADORA3MAPTTP53MPLRXFP1 | |
| SCHEMBL18094532 | 0.81 | TRPV1 (0.45) | ADORA3MAPTTP53MPLRXFP1 | |
| SCHEMBL18094543 | 0.80 | ADORA3 (0.39) | ADORA3MAPTTP53MPL | |
| SCHEMBL18094520 | 0.80 | MPL (0.45) | ADORA3MAPTTP53MPLRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170202849-A1 | ANTIPARASITIC COMPOUNDS | AVISTA PHARMA SOLUTIONS, INC. | 2017-07-20 | — | — | US | claimed |
| US-9643963-B2 | Antiparasitic compounds | AVISTA PHARMA SOLUTIONS, INC. (US) | 2017-05-09 | — | — | US | claimed |
| US-20160280700-A1 | ANTIPARASITIC COMPOUNDS | SNAPDRAGON CHEMISTRY, INC. | 2016-09-29 | — | — | US | claimed |
| EP-3082821-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions, Inc. (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015073797-A1 | ANTIPARASITIC COMPOUNDS | SCYNEXIS INC. (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280700-A1 | ANTIPARASITIC COMPOUNDS | TPP2, TPP1, SERPINB1 | HTT 283/4885KDM4E 3999/4885KMT2A 3102/4885 |
| US-20170202849-A1 | ANTIPARASITIC COMPOUNDS | TPP2, TPP1, SERPINB1 | HTT 283/4885KDM4E 3999/4885KMT2A 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.