Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1RN | P18510 | 1/20 | 0.66 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.66 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.66 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.59 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | CYTH2 | Q99418 | 2/20 | 0.56 |
| ▸ | UQCRB | P14927 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720181 | 0.91 | HSD17B2 (0.71) | IL1RNKEAP1ERAP1PGRPOLB | |
| SCHEMBL3259769 | 0.89 | HSD17B2 (0.73) | IL1RNKEAP1ERAP1PGRPOLB | |
| SCHEMBL8081768 | 0.87 | KEAP1 (0.79) | IL1RNKEAP1ERAP1PGRPOLB | |
| SCHEMBL28930344 | 0.85 | IL1RN (0.64) | IL1RNKEAP1ERAP1PGRPOLB | |
| SCHEMBL16719870 | 0.85 | KMT2A (0.68) | PGRPOLBPKMKMT2AMEN1 | |
| SCHEMBL28271799 | 0.83 | HTR6 (0.71) | POLBPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL16719693 | 0.83 | MAPT (0.61) | PGRPOLBPKMKMT2AMEN1 | |
| SCHEMBL7824383 | 0.82 | UQCRB (0.72) | IL1RNKEAP1ERAP1PGRPKM | |
| SCHEMBL14395901 | 0.82 | PGR (0.70) | IL1RNKEAP1ERAP1PGRPOLB | |
| SCHEMBL18995909 | 0.81 | STAT3 (0.64) | IL1RNKEAP1ERAP1PGRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |