Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30061113 | 0.72 | NOS1 (0.59) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL276869 | 0.72 | NOS1 (0.59) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL3064844 | 0.71 | NOS1 (0.63) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL16719662 | 0.70 | NOS1 (0.52) | NOS1MAPTHSP90AA1IDO1CDK2 | |
| SCHEMBL14231151 | 0.70 | NOS1 (0.61) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL16719842 | 0.69 | AHR (0.48) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL16720036 | 0.69 | NOS1 (0.39) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL276868 | 0.68 | NOS1 (0.59) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL1911926 | 0.68 | NOS1 (0.59) | NOS1MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL655480 | 0.68 | NOS1 (0.59) | NOS1MAPTHSD17B10TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |