Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 9/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720362 | 0.89 | FGFR1 (0.55) | GSK3BCLK2CDK5DYRK1ACLK4 | |
| SCHEMBL16719750 | 0.77 | NPC1 (0.50) | GAA | |
| SCHEMBL27663175 | 0.76 | TRPA1 (0.68) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL27663173 | 0.72 | FGFR1 (0.74) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16719957 | 0.71 | TRPA1 (0.50) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16720437 | 0.71 | QPCT (0.47) | QPCTQPCTLKDM4EMEN1ALDH1A1 | |
| SCHEMBL16720494 | 0.71 | TYR (0.46) | TRPA1LCKBTKKDM4EMEN1 | |
| SCHEMBL2455100 | 0.70 | GSK3B (1.00) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16720263 | 0.70 | METAP2 (0.50) | AURKBROCK2JAK2KDRROCK1 | |
| SCHEMBL16720813 | 0.70 | NOS1 (0.42) | CDK5CLK4DYRK1BKDRROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |