Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 9/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 8/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719958 | 0.79 | HPGDS (0.40) | CYP3A4CHRNB4CHRNA3CYP17A1CYP11B1 | |
| SCHEMBL6211007 | 0.79 | RAB9A (0.46) | CYP2C9METAP2CHRNB4CHRNA3 | |
| SCHEMBL27625438 | 0.79 | HSD17B1 (0.68) | HSD17B1HSD17B2CYP19A1CYP3A4CYP2C9 | |
| SCHEMBL27783403 | 0.79 | PRKCI (0.50) | PIK3CDPIK3CACHRNB4CHRNA3CYP11B1 | |
| SCHEMBL28035390 | 0.78 | FYN (0.46) | CDK1 | |
| SCHEMBL468098 | 0.77 | NPC1 (0.42) | CYP11B1 | |
| SCHEMBL28001501 | 0.76 | CLK4 (0.68) | CYP3A4CYP2C9 | |
| SCHEMBL11105129 | 0.76 | KIF11 (0.50) | HDAC6 | |
| SCHEMBL28035391 | 0.73 | CLK4 (0.34) | — | |
| SCHEMBL23630338 | 0.71 | HSD17B1 (0.62) | HSD17B1HSD17B2CYP19A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |