Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720346 | 0.88 | HPGDS (0.39) | HPGDSKEAP1FAAHMGLLCDC7 | |
| SCHEMBL4276830 | 0.82 | MGLL (0.36) | MGLLCDC7CDK2KMT2AROCK2 | |
| SCHEMBL16719968 | 0.82 | FGFR1 (0.40) | CDC7CDK2KMT2AMAPTROCK2 | |
| SCHEMBL16720096 | 0.82 | MAPT (0.42) | CDC7CDK2KMT2AMAPTROCK2 | |
| SCHEMBL16720656 | 0.81 | KCNH2 (0.45) | MGLLCDC7CDK2ROCK1MAPT | |
| SCHEMBL145426 | 0.80 | BIRC5 (0.44) | BIRC5 | |
| SCHEMBL13045101 | 0.79 | BIRC5 (0.51) | HPGDSKEAP1FAAHMGLLCDC7 | |
| SCHEMBL16720387 | 0.78 | CFTR (0.38) | ROCK2PIM1PIM3 | |
| SCHEMBL16720474 | 0.77 | ROCK2 (0.55) | ROCK2PIM1PIM3 | |
| SCHEMBL16719663 | 0.76 | MAPT (0.34) | CDC7CDK2ROCK1MAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |