Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15515417 | 0.75 | NOS1 (0.49) | NOS1AXLIDO1METAP2TRPV1 | |
| SCHEMBL28458675 | 0.74 | TRPV1 (0.49) | NOS1AXLIDO1METAP2TRPV1 | |
| SCHEMBL26684035 | 0.73 | NOS1 (0.42) | NOS1AXLIDO1METAP2METTL3 | |
| SCHEMBL12842830 | 0.73 | HTR6 (0.58) | NOS1AXLALDH1A1 | |
| SCHEMBL28199257 | 0.71 | NOS1 (0.57) | NOS1AXLIDO1METAP2JAK2 | |
| SCHEMBL16720217 | 0.70 | NOS1 (0.52) | NOS1IDO1HSP90AA1CDK2ALDH1A1 | |
| SCHEMBL719180 | 0.70 | IDO1 (0.45) | NOS1AXLIDO1METAP2METTL3 | |
| SCHEMBL26259567 | 0.70 | ALDH1A1 (0.52) | ALDH1A1MAPT | |
| SCHEMBL12601112 | 0.70 | NOS1 (0.61) | NOS1AXLIDO1METAP2JAK2 | |
| SCHEMBL16719806 | 0.69 | ADRB1 (0.54) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |