Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720399 | 0.91 | TGFBR1 (0.46) | TGFBR1PDPK1IKBKETBK1RPS6KA5 | |
| SCHEMBL16720483 | 0.75 | PDPK1 (0.45) | TGFBR1PDPK1IKBKETBK1RPS6KA5 | |
| SCHEMBL16719998 | 0.73 | PDPK1 (0.45) | TGFBR1PDPK1IKBKETBK1RPS6KA5 | |
| SCHEMBL16719799 | 0.71 | CDK9 (0.55) | TGFBR1PDPK1IKBKETBK1CDK2 | |
| SCHEMBL16720350 | 0.70 | CAMKK2 (0.60) | TGFBR1PDPK1IKBKETBK1CDK2 | |
| SCHEMBL16719631 | 0.70 | CDC7 (0.51) | TGFBR1PDPK1IKBKETBK1RPS6KA5 | |
| SCHEMBL16720531 | 0.70 | BRD4 (0.57) | TGFBR1PDPK1IKBKETBK1CDK2 | |
| SCHEMBL730566 | 0.69 | L3MBTL1 (0.46) | BRD4 | |
| SCHEMBL5618155 | 0.69 | TGFBR1 (0.71) | TGFBR1PDPK1IKBKETBK1RPS6KA5 | |
| SCHEMBL16720572 | 0.69 | TGFBR1 (0.50) | TGFBR1PDPK1IKBKETBK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |