Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 6/20 | 0.50 |
| ▸ | UQCRB | P14927 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720320 | 0.79 | ALDH1A1 (0.47) | ALDH1A1LMNAHTTPKMKMT2A | |
| SCHEMBL16720108 | 0.77 | CA2 (0.50) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL27182682 | 0.74 | HSD17B2 (0.56) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL9307026 | 0.74 | HSD17B2 (0.67) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL27182980 | 0.73 | HSD17B2 (0.58) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL11126460 | 0.71 | HSD17B2 (0.55) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL16720181 | 0.71 | HSD17B2 (0.71) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL16720704 | 0.71 | HSD17B2 (0.46) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL20963122 | 0.70 | HSD17B2 (0.54) | HSD17B2UQCRBALDH1A1KDM4ELMNA | |
| SCHEMBL19997242 | 0.70 | UQCRB (0.59) | HSD17B2UQCRBALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |