Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720612 | 0.82 | ALDH1A1 (0.43) | KMT2APKMMEN1ALDH1A1HPGD | |
| SCHEMBL16720523 | 0.77 | HSD17B2 (0.50) | KMT2APKMMEN1ALDH1A1HTT | |
| SCHEMBL16720320 | 0.77 | ALDH1A1 (0.47) | KMT2APKMMEN1ALDH1A1CA12 | |
| SCHEMBL14080961 | 0.77 | KMT2A (0.42) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL7839074 | 0.71 | FKBP1A (0.66) | KMT2AMEN1ALDH1A1HPGDPOLB | |
| SCHEMBL6005110 | 0.71 | CA2 (0.64) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL59151 | 0.71 | KEAP1 (0.64) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL2512424 | 0.69 | FKBP1A (0.69) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL23141160 | 0.69 | KEAP1 (0.61) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL21692802 | 0.68 | CA1 (0.34) | CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |