Biotin

Biotin

SCHEMBL1672383

O=C(O)C(Cc1ccc(O)cc1)N[N+](=O)[O-].O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.58
▸ MEN1 O00255 1/20 0.58
▸ ABL1 P00519 1/20 0.58
▸ LMNA P02545 1/20 0.58
▸ PKM P14618 1/20 0.58
▸ IDE P14735 1/20 0.58
▸ MAPK1 P28482 1/20 0.58
▸ KMT2A Q03164 1/20 0.58
▸ RIN1 Q13671 1/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ CA12 O43570 10/20 0.48
▸ CA1 P00915 10/20 0.48
▸ CA2 P00918 10/20 0.48
▸ CA9 Q16790 10/20 0.48
▸ FOLH1 Q04609 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1672385 0.87 TDP1 (0.68) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28281161 0.86 TDP1 (0.60) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL3486834 0.85 TDP1 (0.59) TDP1MEN1ABL1LMNAPKM
SCHEMBL5804927 0.84 TDP1 (0.55) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL10618578 0.83 TDP1 (0.65) TDP1MEN1ABL1LMNAPKM
SCHEMBL7259931 0.79 TDP1 (0.49) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23124079 0.78 TDP1 (0.81) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL27800557 0.78 TDP1 (0.85) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL7749208 0.78 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1757916 0.78 TDP1 (0.69) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8632994-B2 Methods and compositions for immuno-histochemical detection DAKO DENMARK A/S (DK) 2014-01-21 — — US claimed
EP-1697750-B1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION DAKO DENMARK AS (DK) 2013-03-20 — — EP claimed
EP-1697750-A1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION Dako Denmark A/S (DK) 2006-09-06 — — EP claimed
US-20050208529-A1 Methods and compositions for immuno-histochemical detection DAKO DENMARK APS (DK) 2005-09-22 — — US claimed
WO-2005054860-A1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION DAKO DENMARK A/S (DK) 2005-06-16 — — WO claimed
US-20240077489-A1 STYRYL PHENOLS, DERIVATIVES AND THEIR USE IN METHODS OF ANALYTE DETECTION AAT BIOQUEST, INC. 2024-03-07 — — US disclosed
US-11821901-B2 Styryl phenols, derivatives and their use in methods of analyte detection AAT BIOQUEST, INC. (US) 2023-11-21 — — US disclosed
US-11237170-B2 Styryl phenols, derivatives and their use in methods of analyte detection AAT BIOQUEST, INC. (US) 2022-02-01 — — US disclosed
US-20200378975-A1 STYRYL PHENOLS, DERIVATIVES AND THEIR USE IN METHODS OF ANALYTE DETECTION AAT BIOQUEST, INC. (US) 2020-12-03 — — US disclosed
US-20200292535-A1 METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE DAKO DENMARK A/S (DK) 2020-09-17 — — US disclosed
US-10718777-B2 Combined histological stain AGILENT TECHNOLOGIES, INC. (US) 2020-07-21 — — US disclosed
US-20200174006-A1 Styryl phenols, derivatives and their use in methods of analyte detection AAT BIOQUEST, INC. 2020-06-04 — — US disclosed
US-20100240085-A1 CONJUGATE MOLECULES DAKO DENMARK APS (DK) 2010-09-23 — — US disclosed
WO-2010094284-A1 METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS DAKO DENMARK A/S (DK) 2010-08-26 — — WO disclosed
WO-2010094283-A1 CONJUGATE MOLECULES DAKO DENMARK A/S (DK) 2010-08-26 — — WO disclosed
EP-2201058-A2 A RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS Dako Denmark A/S (DK) 2010-06-30 — — EP disclosed
WO-2009036760-A2 A RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS DAKO DENMARK A/S (DK) 2009-03-26 — — WO disclosed
EP-1697750-A1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION Dako Denmark A/S (DK) 2006-09-06 — — EP disclosed
US-20050208529-A1 Methods and compositions for immuno-histochemical detection DAKO DENMARK APS (DK) 2005-09-22 — — US disclosed
WO-2005054860-A1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION DAKO DENMARK A/S (DK) 2005-06-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11821901-B2 Styryl phenols, derivatives and their use in methods of analyte detection STUB1, SPR, HLCS TDP1 1177/4885MEN1 4768/4885ABL1 1538/4885
US-20200174006-A1 Styryl phenols, derivatives and their use in methods of analyte detection STUB1, SPR, HLCS TDP1 1177/4885MEN1 4768/4885ABL1 1538/4885
US-20240077489-A1 STYRYL PHENOLS, DERIVATIVES AND THEIR USE IN METHODS OF ANALYTE DETECTION STUB1, SPR, HLCS TDP1 1177/4885MEN1 4768/4885ABL1 1538/4885
US-11237170-B2 Styryl phenols, derivatives and their use in methods of analyte detection STUB1, SPR, HLCS TDP1 1177/4885MEN1 4768/4885ABL1 1538/4885
US-20200378975-A1 STYRYL PHENOLS, DERIVATIVES AND THEIR USE IN METHODS OF ANALYTE DETECTION STUB1, SPR, HLCS TDP1 1177/4885MEN1 4768/4885ABL1 1538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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