Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20848427 | 0.84 | ALDH1A1 (0.36) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 | |
| SCHEMBL1562108 | 0.80 | ALDH1A1 (0.48) | ALDH1A1HSD17B10LMNAGAAALOX15 | |
| SCHEMBL9068703 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 | |
| SCHEMBL1770642 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 | |
| SCHEMBL196658 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 | |
| SCHEMBL23473944 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 | |
| SCHEMBL13718845 | 0.74 | MGAM (0.44) | ALDH1A1HSD17B10LMNAGAAALOX15 | |
| SCHEMBL4755149 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HSD17B10LMNAGAAALOX15 | |
| SCHEMBL1333841 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HSD17B10LMNAGAAALOX15 | |
| SCHEMBL290478 | 0.73 | ALDH1A1 (0.37) | ALDH1A1HSD17B10LMNAHDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4695239-A1 | DISUBSTITUTED PYRIMIDINE COMPOUNDS FOR KETOHEXOKINASE INHIBITION | Centennial Therapeutics, LLC (US) | 2026-02-18 | — | — | EP | disclosed |
| US-20240409530-A1 | Disubstituted Pyrimidine Compounds for Ketohexokinase Inhibition | CENTENNIAL THERAPEUTICS, LLC | 2024-12-12 | — | — | US | disclosed |
| WO-2024216034-A1 | DISUBSTITUTED PYRIMIDINE COMPOUNDS FOR KETOHEXOKINASE INHIBITION | CENTENNIAL THERAPEUTICS, LLC (US) | 2024-10-17 | — | — | WO | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-9067938-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| EP-2611808-B1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| EP-2611808-B1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-8859775-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859775-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859775-B2 | Pyrazolopyridinone derivatives as LPA receptor antagonists | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2611808-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | Merck Patent GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| WO-2012028243-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028243-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350046-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | ALDH1A1 985/4885HSD17B10 1429/4885LMNA 1353/4885 |
| US-20240409530-A1 | Disubstituted Pyrimidine Compounds for Ketohexokinase Inhibition | KHK, GCK, HK1 | ALDH1A1 1031/4885HSD17B10 805/4885LMNA 4402/4885 |
| US-20130165478-A1 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | ALDH1A1 985/4885HSD17B10 1429/4885LMNA 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.