SCHEMBL290478

SCHEMBL290478

CCOC(=O)C(Cl)C(=O)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HDAC4 P56524 2/20 0.35
HDAC6 Q9UBN7 2/20 0.35
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
ALOX15 P16050 1/20 0.34
MGAM O43451 1/20 0.34
GAA P10253 1/20 0.34
SI P14410 1/20 0.34
MGAM2 Q2M2H8 1/20 0.34
SOAT1 P35610 1/20 0.34
POLB P06746 1/20 0.34
MMP8 P22894 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TRPA1 O75762 1/20 0.32
GPR35 Q9HC97 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8971069 0.86 ALDH1A1 (0.36) ALDH1A1KMT2AMEN1LMNAHSD17B10
SCHEMBL882685 0.84 ALDH1A1 (0.34) ALDH1A1KMT2AMEN1LMNAHSD17B10
SCHEMBL65116 0.81 ALDH1A1 (0.39) ALDH1A1KMT2ALMNAHSD17B10ALOX15
SCHEMBL28422244 0.81 ALDH1A1 (0.39) ALDH1A1KMT2AMEN1LMNAHSD17B10
SCHEMBL9218455 0.80 ALDH1A1 (0.34) ALDH1A1KMT2AMEN1LMNAHSD17B10
SCHEMBL1444159 0.79 ALDH1A1 (0.50) ALDH1A1KMT2AMEN1LMNAHSD17B10
SCHEMBL9068703 0.78 ALDH1A1 (0.40) ALDH1A1LMNAHSD17B10HDAC4HDAC6
SCHEMBL23473944 0.77 ALDH1A1 (0.39) ALDH1A1KMT2ALMNAHSD17B10HDAC4
SCHEMBL1770642 0.77 ALDH1A1 (0.39) ALDH1A1LMNAHSD17B10HDAC4HDAC6
SCHEMBL196658 0.77 ALDH1A1 (0.39) ALDH1A1KMT2ALMNAHSD17B10HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 319 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354902-A Green and environment-friendly process for synthesizing 2-methyl-4-trifluoromethyl-5-thiazole formic acid 广东禾康精细化工有限公司 2023-06-30 CN claimed
CN-106905153-B Method for preparing 2-chloro-4,4, 4-trifluoroacetylacetic acid ethyl ester by continuous non-catalytic reaction 浙江蓝天环保高科技股份有限公司 2020-08-18 CN claimed
EP-3658701-A1 PROCESS FOR THE PREPARATION OF METALLIC NANO-PARTICLE LAYERS AND THEIR USE FOR DECORA-TIVE OR SECURITY ELEMENTS BASF SE (DE) 2020-06-03 EP claimed
CN-110832110-A Method for producing a metal nanoparticle layer and use thereof in decorative or security elements 巴斯夫欧洲公司 2020-02-21 CN claimed
WO-2019020682-A1 PROCESS FOR THE PREPARATION OF METALLIC NANO-PARTICLE LAYERS AND THEIR USE FOR DECORA-TIVE OR SECURITY ELEMENTS BASF SE (DE) 2019-01-31 WO claimed
CN-106905153-A A kind of method that continuous non-catalytic reaction prepares the chloro- 4,4,4- trifluoroacetic ethyl acetoacetates of 2- 浙江蓝天环保高科技股份有限公司 2017-06-30 CN claimed
US-5880288-A Process for the preparation of 2-methylthiazole-5-carboxylates ROHM AND HAAS COMPANY (US) 1999-03-09 US claimed
EP-0607795-B1 Process for the preparation of 2-alkyl-4-fluoromethyl-thiazole-carboxylic acid esters BASF AG (DE) 1995-10-04 EP claimed
US-5442073-A Preparation of alkyl 2-alkyl-4-fluoromethylthiazolecarboxylates BASF AKTIENGESELLSCAHFT (DE) 1995-08-15 US claimed
EP-0650963-A1 Improved process for the preparation of 2-methylthiazole-5-carboxylates ROHM AND HAAS COMPANY (US) 1995-05-03 EP claimed
JP-6298748-A None JP disclosed
EP-4747256-A1 PARP1 INHIBITOR COMPOUNDS Duke Street Bio Limited (GB) 2026-05-27 EP disclosed
US-12570666-B2 Furoindazole derivatives BAYER AKTIENGESELLSCHAFT (DE) 2026-03-10 US disclosed
EP-4570313-A2 CYANOTRIAZOLE COMPOUNDS Otsuka Pharmaceutical Co., Ltd. (JP) 2025-06-18 EP disclosed
EP-4077334-B1 FUROINDAZOLE DERIVATIVES BAYER AG (DE) 2025-03-12 EP disclosed
US-4647689-A Preparation of alkyl trifluoroacetoacetate MONSANTO COMPANY (US) 1987-03-03 US disclosed
EP-0027020-B1 2-SUBSTITUTED-4-ALKYL OR TRIHALOALKYL-5-OXAZOLECARBOXYLIC ACID DERIVATIVES, THEIR USE AS SAFENING AGENTS AND HERBICIDAL COMPOSITIONS CONTAINING THEM MONSANTO COMPANY (US) 1983-04-13 EP disclosed
US-4360678-A PLANT SAFENING AGENT MONSANTO COMPANY (US) 1982-11-23 US disclosed
US-4303439-A ANTIDOTES TO REDUCE HERBICIDAL INJURY MONSANTO COMPANY (US) 1981-12-01 US disclosed
EP-0027020-A1 2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acid derivatives, their use as safening agents and herbicidal compositions containing them MONSANTO COMPANY (US) 1981-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570666-B2 Furoindazole derivatives FURIN, CYP2F1, CYP3A7 ALDH1A1 510/4885KMT2A 4493/4885MEN1 426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.