SCHEMBL196658

SCHEMBL196658

CCOC(=O)C(C)C(=O)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
HPGD P15428 1/20 0.39
MMP8 P22894 1/20 0.38
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
HDAC4 P56524 2/20 0.36
HDAC6 Q9UBN7 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
ALOX15 P16050 1/20 0.36
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
SOAT1 P35610 1/20 0.36
POLB P06746 1/20 0.35
TRPA1 O75762 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KMT2A Q03164 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23473944 1.00 ALDH1A1 (0.39) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL25177337 0.86 ALDH1A1 (0.34) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL19024090 0.85 ALDH1A1 (0.41) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL7101062 0.85 ALDH1A1 (0.38) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL9068703 0.80 ALDH1A1 (0.40) ALDH1A1MMP8LMNAHSD17B10HDAC4
SCHEMBL2319054 0.80 ALDH1A1 (0.40) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL1770642 0.78 ALDH1A1 (0.39) ALDH1A1MMP8LMNAHSD17B10HDAC4
SCHEMBL141446 0.78 ALDH1A1 (0.53) ALDH1A1HPGDMMP8LMNAHSD17B10
SCHEMBL18643783 0.77 SMN1; SMN2 (0.39) ALDH1A1HPGDPOLBKMT2A
SCHEMBL290478 0.77 ALDH1A1 (0.37) ALDH1A1MMP8LMNAHSD17B10HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056539-A4 NICKEL DIIMINE CATALYSTS WITH METHYLALUMOXANE AS COCATALYST, METHOD OF POLYMERIZATION OF OLEFINS THEREWITH AND POLYMERS PRODUCED CONOCOPHILLIPS CO (US) 2005-01-26 EP claimed
US-6821920-B2 DIIMINE NICKEL COMPLEXES CONTAINING ACETYLACETONATE, HEXAFLUOROACETYLACETONATE, AND/OR HALOGEN LIGANDS FOR SLURRY POLYMERIZATION OF ALPHA-OLEFINS PHILLIPS PETROLEUM COMPANY 2004-11-23 US claimed
US-20030134996-A1 Polymerization catalysts and processes therefor PHILLIPS PETROLEUM COMPANY (US) 2003-07-17 US claimed
US-6521727-B2 Slurry polymerization reactor contains ethylene monomer, heterogenous catalyst comprising methylaluminoxane and diimine nickel complexes; for producing high molecular weight polymers from olefins PHILLIPS PETROLEUM COMPANY 2003-02-18 US claimed
US-6479422-B1 CATALYSTS SELECTED FROM THE GROUP CONSISTING OF DIIMINE NICKEL (II) COMPLEXES AND DIIMINE PALLADIUM (II) COMPLEXES PHILLIPS PETROLEUM COMPANY 2002-11-12 US claimed
US-20020016426-A1 Polymerization catalysts and processes therefor EILERTS NANCY W (US) 2002-02-07 US claimed
US-6291608-B1 CONTACTING MONO-1-OLEFIN IN POLYMERIZATION ZONE, UNDER POLYMERIZATION CONDITIONS, WITH A DUAL CATALYST SYSTEM COMPRISING METALLOCENE CATALYST AND COCATALYST AND SECOND CATALYST COMPRISING DIIMINE NICKEL COMPLEX; RECOVERING PHILLIPS PETROLEUM COMPANY 2001-09-18 US claimed
EP-1056539-A1 NICKEL DIIMINE CATALYSTS WITH METHYLALUMOXANE AS COCATALYST, METHOD OF POLYMERIZATION OF OLEFINS THEREWITH AND POLYMERS PRODUCED Phillips Petroleum Company (US) 2000-12-06 EP claimed
WO-1999032226-A1 NICKEL DIIMINE CATALYSTS WITH METHYLALUMOXANE AS COCATALYST, METHOD OF POLYMERIZATION OF OLEFINS THEREWITH AND POLYMERS PRODUCED PHILLIPS PETROLEUM COMPANY (US) 1999-07-01 WO claimed
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2025-08-05 US disclosed
US-20250145572-A1 Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors ORSOBIO INC (US) 2025-05-08 US disclosed
EP-4434982-A1 (S)-2-(2-METHYLAZETIDIN-1-YL)PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME LG Chem, Ltd. (KR) 2024-09-25 EP disclosed
EP-4374877-A2 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR AND PHOSPHORUS ADSORBENT FOR USE IN THE PREVENTION, TREATMENT OR SUPPRESSION OF CHRONIC KIDNEY DISEASE, ARTERIOSCLEROSIS ASSOCIATED WITH VASCULAR CALCIFICATION, OR ECTOPIC CALCIFICATION. CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-05-29 EP disclosed
EP-3928779-B1 PHARMACEUTICAL CONTAINING SODIUM-DEPENDENT PHOSPHATE TRANSPORTER INHIBITOR AND PHOSPHORUS ADSORBENT FOR USE IN THE PREVENTION, TREATMENT OR SUPPRESSION OF CHRONIC KIDNEY DISEASE, ARTERIOSCLEROSIS ASSOCIATED WITH VASCULAR CALCIFICATION, OR ECTOPIC CALCIFICATION. CHUGAI PHARMACEUTICAL CO LTD (JP) 2024-03-06 EP disclosed
EP-0396250-A1 Pyrimidinone derivatives ZENECA LIMITED (GB) 1990-11-07 EP disclosed
US-4962024-A ADDING SECOND ENZYME AND BLOCKED FLUOROKETONE INHIBITOR OF THE SECOND ENZYME BECTON, DICKINSON AND COMPANY (US) 1990-10-09 US disclosed
US-4835099-A Signal enhancement in immunoassay by modulation of enzymatic catalysis BECTON, DICKINSON AND COMPANY (US) 1989-05-30 US disclosed
EP-0271731-A2 Signal enhancement in immunoassay by inhibition of enzymatic catalysis Becton, Dickinson and Company (US) 1988-06-22 EP disclosed
EP-0195212-A2 Novel peptidase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1986-09-24 EP disclosed
US-4103256-A BLUE-GREEN TO NEAR ULTRAVIOLET THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 ALDH1A1 370/4885HPGD 311/4885MMP8 2099/4885
US-20250145572-A1 Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors ACMSD, ALDH7A1, ALAD ALDH1A1 271/4885HPGD 395/4885MMP8 1973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.