Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | XDH | P47989 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rubrofusarin SCHEMBL486101 | 0.86 | XDH (0.79) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| Noreugenin SCHEMBL168822 | 0.84 | PTGS2 (0.71) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| Noreugenin SCHEMBL29370130 | 0.84 | PTGS2 (0.71) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| SCHEMBL20020393 | 0.83 | XDH (0.53) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| SCHEMBL15060666 | 0.83 | XDH (0.79) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| SCHEMBL8860206 | 0.83 | XDH (0.46) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| SCHEMBL21671248 | 0.78 | PTGS1 (0.61) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| SCHEMBL31536863 | 0.77 | NUAK1 (0.75) | HSD17B10GAAANTXR2HPGDCYP3A4 | |
| Ustilaginoidin A SCHEMBL3119631 | 0.76 | PTGS1 (0.62) | PTGS1PTGS2MAPTHSD17B10KDM4E | |
| Eugenitol SCHEMBL29881346 | 0.76 | PTGS1 (0.77) | PTGS1PTGS2MAPTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488152-B1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | OREAL (FR) | 2018-04-04 | — | — | EP | claimed |
| US-8551189-B2 | Composition comprising at least one 1,8-dihydroxynaphthalene derivative and at least one basifying agent different from aqueous ammonia, process for dyeing keratin fibres using the composition | L'OREAL (FR) | 2013-10-08 | — | — | US | claimed |
| EP-2488152-A2 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | L'Oréal (FR) | 2012-08-22 | — | — | EP | claimed |
| WO-2011045403-A2 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | L'OREAL (FR) | 2011-04-21 | — | — | WO | claimed |
| EP-2488152-B1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | OREAL (FR) | 2018-04-04 | — | — | EP | disclosed |
| EP-2488152-B1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | OREAL (FR) | 2018-04-04 | — | — | EP | disclosed |
| US-8551189-B2 | Composition comprising at least one 1,8-dihydroxynaphthalene derivative and at least one basifying agent different from aqueous ammonia, process for dyeing keratin fibres using the composition | L'OREAL (FR) | 2013-10-08 | — | — | US | disclosed |
| US-8551189-B2 | Composition comprising at least one 1,8-dihydroxynaphthalene derivative and at least one basifying agent different from aqueous ammonia, process for dyeing keratin fibres using the composition | L'OREAL (FR) | 2013-10-08 | — | — | US | disclosed |
| US-8551189-B2 | Composition comprising at least one 1,8-dihydroxynaphthalene derivative and at least one basifying agent different from aqueous ammonia, process for dyeing keratin fibres using the composition | L'OREAL (FR) | 2013-10-08 | — | — | US | disclosed |
| US-20130219633-A1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | L'OREAL (FR) | 2013-08-29 | — | — | US | disclosed |
| US-20130219633-A1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | L'OREAL (FR) | 2013-08-29 | — | — | US | disclosed |
| WO-2012136782-A1 | METHOD OF DYEING OR MAKING UP KERATIN FIBRES USING A PIGMENT RESULTING FROM A 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE, COMPOSITION CONTAINING THE PIGMENT AND THE PIGMENT | L'OREAL (FR) | 2012-10-11 | — | — | WO | disclosed |
| WO-2011045403-A2 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | L'OREAL (FR) | 2011-04-21 | — | — | WO | disclosed |
| US-5614642-A | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof | SUGEN INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5602171-A | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof | SUGEN INC. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996040109-A1 | METHODS OF INHIBITING PHOSPHATASE ACTIVITY AND TREATMENT OF DISORDERS ASSOCIATED THEREWITH USING NAPHTHOPYRONES AND DERIVATIVES THEREOF | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130219633-A1 | COMPOSITION COMPRISING AT LEAST ONE 1,8-DIHYDROXYNAPHTHALENE DERIVATIVE AND AT LEAST ONE BASIFYING AGENT DIFFERENT FROM AQUEOUS AMMONIA, PROCESS FOR DYEING KERATIN FIBRES USING THE COMPOSITION | KRT18, DSG1, TUBA8 | PTGS1 3787/4885PTGS2 3978/4885MAPT 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.