⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220998 | 0.67 | GPR84 (0.50) | — | |
| SCHEMBL1896344 | 0.67 | — | — | |
| SCHEMBL3362001 | 0.67 | — | — | |
| SCHEMBL1774205 | 0.67 | — | — | |
| SCHEMBL8188652 | 0.67 | — | — | |
| SCHEMBL189997 | 0.67 | — | — | |
| SCHEMBL325682 | 0.67 | — | — | |
| SCHEMBL13918178 | 0.67 | — | — | |
| SCHEMBL60308 | 0.67 | — | — | |
| SCHEMBL317622 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117729917-A | Combination therapy using AKR1C3 activating compounds and immune checkpoint inhibitors | 深圳艾欣达伟医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-113293203-B | RNA 4-mercaptouracil specific labeling method and application thereof | 西安交通大学 | 2022-07-12 | — | — | CN | claimed |
| CN-114746753-A | Correlating AKR1C3 enzyme expression level through prostaglandin content and screening administration application | 深圳艾欣达伟医药科技有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-114350770-A | Double-function marking method of 4-mercaptouracil and application thereof in sequence enrichment and single base resolution sequencing | 西安交通大学 | 2022-04-15 | — | — | CN | claimed |
| CN-113293203-A | RNA 4-mercaptouracil specific labeling method and application thereof | 西安交通大学 | 2021-08-24 | — | — | CN | claimed |
| CN-114728934-B | Heterocyclic derivatives, pharmaceutical compositions and their use for treating or ameliorating cancer | 托雷莫治疗股份公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-118256453-A | Scalable manufacturing method for producing recombinant lentiviral vectors in serum-free suspension cell culture systems | 费城儿童医院 | 2024-06-28 | — | — | CN | disclosed |
| CN-118139642-A | Compositions and methods for treating cancer | 约翰·霍普金斯大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-117729917-A | Combination therapy using AKR1C3 activating compounds and immune checkpoint inhibitors | 深圳艾欣达伟医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117683049-A | Indole derivatives as RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117616031-A | RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-02-27 | — | — | CN | disclosed |
| WO-2014015291-A1 | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX | ZHOU HAN-JIE (US) | 2014-01-23 | — | — | WO | disclosed |
| US-20140024661-A1 | FUSED PYRIMIDINES AND SUBSTITUTED QUINAZOLINES AS INHIBITORS OF P97 | CLEAVE BIOSCIENCES, INC. (US) | 2014-01-23 | — | — | US | disclosed |
| US-8309356-B2 | Pseudocomplementary oligonucleotides for targeted gene therapy | YALE UNIVERSITY (US) | 2012-11-13 | — | — | US | disclosed |
| US-8124417-B2 | Method for analyzing nucleobases on a single molecular basis | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8124417-B2 | Method for analyzing nucleobases on a single molecular basis | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20110086905-A1 | Pseudocomplementary Oligonucleotides for Targeted Gene Therapy | YALE UNIVERSITY | 2011-04-14 | — | — | US | disclosed |
| US-20090155917-A1 | Method for analyzing nucleobases on a single molecular basis | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2009-06-18 | — | — | US | disclosed |
| US-20090155917-A1 | Method for analyzing nucleobases on a single molecular basis | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2009-06-18 | — | — | US | disclosed |