Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 10/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL16735627 | 0.91 | FFAR2 (0.38) | FFAR2SLC6A2SLC6A3MCHR1 | |
| Bicarbonate SCHEMBL16735616 | 0.91 | KMT2A (0.41) | FFAR2SLC6A2SLC6A3LMNA | |
| Bicarbonate SCHEMBL16735547 | 0.90 | PTGES (0.40) | FFAR2LMNAKEAP1NFE2L2 | |
| SCHEMBL10006421 | 0.87 | OPRL1 (0.36) | FFAR2OPRL1IDO1 | |
| Bicarbonate SCHEMBL16735610 | 0.86 | CCR3 (0.36) | FFAR2LMNAKEAP1NFE2L2 | |
| Bicarbonate SCHEMBL16735612 | 0.86 | DGAT1 (0.37) | IDO1KEAP1NFE2L2 | |
| Bicarbonate SCHEMBL16735564 | 0.85 | ACKR3 (0.47) | FFAR2SLC6A2SLC6A3LMNAALDH1A1 | |
| Bicarbonate SCHEMBL9899636 | 0.85 | KMT2A (0.41) | LMNAKEAP1NFE2L2ALDH1A1 | |
| Bicarbonate SCHEMBL16735635 | 0.84 | KMT2A (0.47) | LMNAALDH1A1 | |
| Bicarbonate SCHEMBL16735611 | 0.83 | KLKB1 (0.35) | LMNAKEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649045-B1 | SUBSTITUTED 1-BENZYLCYCLOALKYLCARBOXLIC ACIDS AND USE THEREOF | BAYER IP GMBH (DE) | 2015-05-27 | — | — | EP | disclosed |