Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143809 | 0.82 | EGLN1 (0.49) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL16735589 | 0.81 | HSP90AA1 (0.52) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL16735594 | 0.76 | MEN1 (0.42) | ALDH1A1KDM4EMAPT | |
| SCHEMBL15327100 | 0.72 | HPGD (0.60) | TSHRALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL16735660 | 0.71 | L3MBTL1 (0.54) | TSHRALDH1A1NPSR1 | |
| SCHEMBL16735648 | 0.67 | HSP90AA1 (0.43) | ALDH1A1TP53 | |
| SCHEMBL16735626 | 0.66 | PDK1 (0.46) | TP53 | |
| SCHEMBL16735621 | 0.66 | TP53 (0.43) | ALDH1A1LMNATP53 | |
| SCHEMBL14973878 | 0.66 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EMAPTCA12 | |
| SCHEMBL16735575 | 0.65 | HSP90AA1 (0.58) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |