Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27841531 | 0.86 | CYP1A2 (0.43) | ALDH1A1HSD17B10KDM4EPOLBCYP1A2 | |
| SCHEMBL28007486 | 0.82 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EPOLBCYP1A2 | |
| SCHEMBL27345980 | 0.80 | POLB (0.45) | ALDH1A1HSD17B10KDM4EPOLBHDAC3 | |
| SCHEMBL28310687 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL28058630 | 0.79 | LIPG (0.47) | ALDH1A1TSHRLMNA | |
| SCHEMBL11699661 | 0.78 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4ECYP1A2CYP2C9 | |
| SCHEMBL8756694 | 0.78 | KDM4E (0.49) | ALDH1A1HSD17B10KDM4ECYP2C9HDAC3 | |
| SCHEMBL15486326 | 0.75 | KDM4E (0.47) | ALDH1A1HSD17B10KDM4ECYP2C9HDAC3 | |
| SCHEMBL3523840 | 0.75 | LTA4H (0.46) | ALDH1A1TSHRLMNACYP3A4NR1I2 | |
| SCHEMBL9169265 | 0.75 | LTA4H (0.46) | ALDH1A1TSHRLMNACYP3A4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071582-B1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | RES & INNOVATION UK (GB) | 2020-04-29 | — | — | EP | disclosed |
| EP-3623375-A1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | United Kingdom Research and Innovation (GB) | 2020-03-18 | — | — | EP | disclosed |
| CN-105873936-B | Mitochondrially targeted dicarbonyl chelate compounds | 医药研究委员会 | 2018-09-14 | — | — | CN | disclosed |
| US-9963474-B2 | Mitochondria-targeted dicarbonyl sequestering compounds | MEDICAL RESEARCH COUNCIL (GB) | 2018-05-08 | — | — | US | disclosed |
| US-20160289252-A1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2016-10-06 | — | — | US | disclosed |
| EP-3071582-A1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | Medical Research Council (GB) | 2016-09-28 | — | — | EP | disclosed |
| CN-105873936-A | Mitochondrially targeted dicarbonyl chelate compounds | 医药研究委员会 | 2016-08-17 | — | — | CN | disclosed |
| WO-2015075200-A1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | MEDICAL RESEARCH COUNCIL (GB) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289252-A1 | MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS | NDUFAB1, HADHB, SLC25A21 | ALDH1A1 488/4885HSD17B10 314/4885KDM4E 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.