Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.64 |
| ▸ | CA2 | P00918 | 2/20 | 0.64 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.60 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044959 | 0.88 | L3MBTL1 (0.70) | CA1CA2HSD17B2NLRP3ALDH1A1 | |
| SCHEMBL1748615 | 0.86 | ALDH1A1 (0.75) | CA1CA2HSD17B2NLRP3ALDH1A1 | |
| SCHEMBL26625402 | 0.84 | NLRP3 (0.62) | CA1CA2HSD17B2NLRP3ALDH1A1 | |
| SCHEMBL5177163 | 0.84 | NLRP3 (0.62) | CA1CA2HSD17B2NLRP3LMNA | |
| SCHEMBL392625 | 0.84 | ALDH1A1 (0.82) | CA1CA2HSD17B2ALDH1A1LMNA | |
| SCHEMBL3838048 | 0.83 | ALDH1A1 (0.75) | CA1CA2HSD17B2ALDH1A1LMNA | |
| SCHEMBL10133256 | 0.83 | ALDH1A1 (0.75) | CA1CA2HSD17B2ALDH1A1LMNA | |
| SCHEMBL10598870 | 0.82 | ERCC1 (0.73) | CA1CA2HSD17B2ALDH1A1LMNA | |
| SCHEMBL28992290 | 0.82 | KMT2A (0.61) | CA1CA2HSD17B2ALDH1A1LMNA | |
| SCHEMBL28992291 | 0.82 | ALDH1A1 (0.68) | CA1CA2HSD17B2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105916506-B | Quinazoline derivatives as inhibitors of TAM family kinases | 圣诺康生命科学公司 | 2020-01-07 | — | — | CN | disclosed |
| EP-3071204-B1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORP (CA) | 2019-02-20 | — | — | EP | disclosed |
| EP-3071204-B1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORP (CA) | 2019-02-20 | — | — | EP | disclosed |
| US-9771333-B2 | Quinazoline derivatives as TAM family kinase inhibitors | SIGNALCHEM LIFESCIENCES CORP. (CA) | 2017-09-26 | — | — | US | disclosed |
| US-9771333-B2 | Quinazoline derivatives as TAM family kinase inhibitors | SIGNALCHEM LIFESCIENCES CORP. (CA) | 2017-09-26 | — | — | US | disclosed |
| US-20160297775-A1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORP (CA) | 2016-10-13 | — | — | US | disclosed |
| US-20160297775-A1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORP (CA) | 2016-10-13 | — | — | US | disclosed |
| CN-105916506-A | Quinazoline derivatives as inhibitors of TAM family kinases | 圣诺康生命科学公司 | 2016-08-31 | — | — | CN | disclosed |
| WO-2015077375-A1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORP. (CA) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297775-A1 | QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | MAP3K5, MAP3K1, MAP3K2 | CA1 4622/4885CA2 3024/4885HSD17B2 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.