Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686722 | 0.78 | SMN1; SMN2 (0.40) | ALDH1A1KMT2ATSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL11843092 | 0.78 | ALOX5 (0.43) | ALDH1A1MAPTCYP3A4 | |
| SCHEMBL9915311 | 0.78 | CYP1A2 (0.37) | ALDH1A1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL8170006 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KMT2ATSHRLMNACYP1A2 | |
| SCHEMBL9915310 | 0.77 | NPC1 (0.36) | ALDH1A1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL30017694 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KMT2AATMESR1TSHR | |
| SCHEMBL24047005 | 0.75 | SMN1; SMN2 (0.36) | ALDH1A1KMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL9784701 | 0.75 | TSHR (0.39) | ALDH1A1KMT2ATSHRLMNAMAPK1 | |
| SCHEMBL9915401 | 0.74 | CYP1A2 (0.37) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9915402 | 0.74 | CYP1A2 (0.41) | CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |