Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609628 | 0.92 | PDE4B (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL9915402 | 0.82 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19TLR8SMN1; SMN2 | |
| SCHEMBL9915311 | 0.82 | CYP1A2 (0.37) | CYP1A2CYP2C9CYP2C19TLR8NPC1 | |
| SCHEMBL3571240 | 0.77 | CSNK2A1 (0.35) | TLR8SMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL6608422 | 0.76 | PDE4B (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9915310 | 0.74 | NPC1 (0.36) | CYP1A2CYP2C9CYP2C19TLR8NPC1 | |
| SCHEMBL16748702 | 0.74 | ALDH1A1 (0.44) | CYP1A2CYP2C19SMN1; SMN2PDE4APDE4B | |
| SCHEMBL13412631 | 0.73 | CYP1A2 (0.52) | CYP1A2CYP2C9CYP2C19TLR8SMN1; SMN2 | |
| SCHEMBL27278144 | 0.73 | ALDH1A1 (0.41) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3335759 | 0.73 | NPC1 (0.47) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | CYP1A2 957/4885CYP2C9 975/4885CYP2C19 714/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | CYP1A2 957/4885CYP2C9 975/4885CYP2C19 714/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | CYP1A2 957/4885CYP2C9 975/4885CYP2C19 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.