Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124916 | 0.77 | CYP19A1 (0.43) | NPC1RAB9ACYP19A1CA1CA2 | |
| SCHEMBL16748702 | 0.77 | ALDH1A1 (0.44) | CA9TSHRALDH1A1LMNAMAPT | |
| SCHEMBL17974336 | 0.75 | NAAA (0.38) | NPC1RAB9ACA1CA2CA12 | |
| SCHEMBL9915401 | 0.74 | CYP1A2 (0.37) | NPC1RAB9ATSHRALDH1A1GAA | |
| SCHEMBL9915402 | 0.74 | CYP1A2 (0.41) | NPC1RAB9AKDM4ETLR8CYP1A2 | |
| SCHEMBL9915311 | 0.74 | CYP1A2 (0.37) | NPC1RAB9AALDH1A1MEN1GAA | |
| SCHEMBL17553854 | 0.72 | CA1 (0.44) | NPC1RAB9ACA1CA2CA12 | |
| SCHEMBL15273807 | 0.72 | PRKDC (0.33) | TSHRALDH1A1LMNAGAAMAPT | |
| SCHEMBL6608422 | 0.69 | PDE4B (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9915365 | 0.68 | MAPT (0.44) | NPC1RAB9ATSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | NPC1 3628/4885RAB9A 2614/4885PDE3B 2988/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | NPC1 3628/4885RAB9A 2614/4885PDE3B 2988/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | NPC1 3628/4885RAB9A 2614/4885PDE3B 2988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.